Relationship Between low vitamin d and high cholesterol

Vitamin D might make the ratio of total cholesterol to HDL cholesterol better. This is what the first research showed. So far, most applications of vitamin D have focused on how it affects calcium metabolism and, by extension, bone structure and the immune system. Based on a study from 2017, the effect on blood lipid levels could soon be added to this.

The level of cholesterol shows a lot of different things. The LDL and HDL values, as well as the total cholesterol level, are the most well-known. low vitamin d and high cholesterol,The levels of both total and LDL should be as low as possible. On the other hand, the HDL value should be 40 mg/dl or higher. There are also other ways to evaluate something.

The ratio of total cholesterol to HDL is the most important of these. This is called the cholesterol quotient. To figure it out, divide the total by the HDL value. Doctors think that the ratio of total cholesterol to HDL tells them more about cardiovascular risks than, say, an LDL value that might be higher on its own. If the cholesterol quotient is five or higher (for example, 200/40=5), there is a higher risk.

People who are healthy should have a quotient of 4.4 or less (for example, 195/45 = 4.33). If the value is 3.3, for example, the risk of heart disease is cut in half (165/50=3.3). Even small changes in cholesterol levels can move someone from the risk group to the normal group. This is shown by the examples in brackets.[1]

Does vitamin D level affect cholesterol levels ?

If vitamin D deficiencies are fixed, that could already be a big step in the right direction. Scientists from Johns Hopkins University in Baltimore, Maryland, USA, led a study that found evidence of this exact link. To do this, the researchers looked at data from the Atherosclerosis Risk in Communities (ARIC) study that was collected from more than 13,000 people with an average age of 57. ARIC is a long-term project that has been going on since 1987 with the help of many universities and other research institutions to find and study risk factors for arterial calcification.

Poor cholesterol quotient in vitamin D deficiency

The scientists from Hopkins were now interested in how much vitamin D the people took. To be more exact, they looked at the levels of calcidiol and 25(OH)vitamin D3. This is the form of vitamin D that the body stores and can turn into 1,25(OH)2-vitamin D3 (calcitriol) when it needs to. If the 25(OH)vitamin D3 level is less than 20 ng/ml, there is a lack of vitamin D.

learn more about  The Oxidized Cholesterol Strategy

A value of 30 ng/ml means that there is a good amount. In this study, the researchers found that a lack of vitamin D was also linked to an average HDL level that was 3.02 mg/dl lower and a cholesterol ratio that was 0.18 higher. Other things that could have had an effect have already been ruled out. But the scientists were not able to find any changes in the levels of triglycerides or LDL that were related to the levels of vitamin D.

If you have a problem with how your body handles fat, check for a lack of vitamin D.

At this point, US researchers can’t say anything about the cause-and-effect link between vitamin D levels and the cholesterol quotient either. Their work was one of the first in this field, but it only shows what people have seen. Still, the study’s authors suggest taking vitamin D as a supplement if you don’t get enough of it. This is especially important if you have dyslipidemia.

Vitamins are a natural way to treat high cholesterol.

How some micronutrients naturally lower cholesterol and stop other diseases from happening

reasons and signs

treatment goals

Micronutrients as a treatment

Vote in favor of medicines with micronutrients


Studies and sources listed

Date of last change: June 21, 2022

Drugs that lower cholesterol are some of the most commonly prescribed drugs. But what many people don’t know is that high cholesterol (hypercholesterolemia) can also be treated naturally. Some micronutrients help get rid of cholesterol or stop it from being made. Others keep diseases from getting into the blood vessels. In this article, you’ll find out which micronutrients help lower cholesterol in a natural way.

The feet are a body scale.

If you are overweight and have high cholesterol, losing weight can already lower your cholesterol level. Rostislav Sedlacek/iStock/Getty Images Plus

reasons and signs

High cholesterol levels can be caused by a number of things (hypercholesterolaemia). The most common reason is a combination of an unhealthy lifestyle and genetics: the body makes too much cholesterol on its own. A diet high in fat, sugar, alcohol, or cigarettes, being overweight, and not getting enough exercise all play a role. This is the case in 60–70% of situations.

But high cholesterol can also be caused by diseases like diabetes and hypothyroidism. There are also forms that are only passed down through families. Changes in the DNA can mess up the way the body uses cholesterol. Those who are affected then feel the effects very quickly, like a heart attack.


When figuring out if your cholesterol level is too high, the amount of bad LDL-cholesterol is what matters. [more info]

About 40% of people in Germany over the age of 65 have high cholesterol. But you can’t tell at first glance because there are usually no signs. So, the people who are hurt often don’t know about it. Only a lab test can tell if the levels of lipids in the blood are higher than the limit value.

learn more about  The Oxidized Cholesterol Strategy

If the cholesterol level is always too high, it can hurt the heart and blood vessels, especially when the bad LDL cholesterol builds up in the blood vessels. It can be hurt later (oxidize). This, in turn, hurts the walls of the vessel. If the LDL level stays too high for too long, the blood vessels get smaller and the arteries harden. This is called atherosclerosis. Also, the good HDL cholesterol that protects blood vessels is usually too low. Some of the problems that can happen are high blood pressure, a heart attack, or a stroke.

Start over

treatment goals

How has high cholesterol been treated in the past?

Most of the time, medications are used to treat high cholesterol. In Germany, doctors mostly give statins. Nine out of ten people who take drugs to lower their blood fat take statins. These include atorvastatin (like Sortis®, Atoris®), fluvastatin (like Cranoc®, Locol®), lovastatin (like Mevinacor®), pravastatin (like Mevalotin®, Pravagamma®), rosuvastatin (like Rosuvastatin ratiopharm®, Crestor®), or simvastatin (like Zocor®, SimvaHEXAL®).[2]

Fibrates, like bezafibrate (like Befibrate® and Bezafibrate AL®) and fenofibrate (like Lipidil® and Lipanthyl®), and the anion exchange resin colestyramine (like Lipocol® and Quantalan®), are also used to lower cholesterol.


If you are overweight, doctors will tell you to lose weight: [more info]

What micronutrient medicine wants to do

Cholesterol levels depend on what you eat. Because of this, you should eat a well-balanced diet with lots of vegetables and whole grain foods. The level of cholesterol can also be controlled by getting the right amount of micronutrients. low vitamin d and high cholesterol, Some micronutrients lower high cholesterol levels and lower the risk of secondary diseases like hardening of the arteries, high blood pressure, and heart attacks.[3]

The most important nutrients for healthy blood vessels and low cholesterol are:

Dietary fibers like glucomannan and beta-glucans from oats are good for your health.

Artichoke leaves and grapes are used to make botanicals.

Vitamin D

Phospholipids like phosphatidylcholine

antioxidant vitamins and minerals

B vitamins

Fatty acids with omega-3


Red mold rice, which has been fermented, is also known for lowering cholesterol. [more info]

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Micronutrients as a treatment

Glucomannan makes it harder for the body to absorb cholesterol from food.

The way glucomannan works

A special kind of fiber called glucomannan comes from the konjac root. With water in the digestive tract, it swells up a lot and forms a gel. This makes things better:

Glucomannan slows down the emptying of the stomach, so nutrients are broken down more slowly. Then, insulin levels rise less, which means the body makes less cholesterol on its own.

The gel that forms in the small intestine stops cholesterol from being taken in from food.

In the large intestine, bacteria break down glucomannan into short-chain fatty acids. There is evidence that these help control how much cholesterol is made in the liver.

High cholesterol may go down on its own if you eat glucomannan. Researchers found that LDL cholesterol went down by 10 percent, or 16 milligrams per deciliter, in two different studies. Also, total cholesterol went down. Another review shows that glucomannan improves the metabolism in other ways as well. Triglycerides, blood sugar, blood pressure, and weight all go down. This makes other risks for heart health less likely.correlation between low vitamin d and high cholesterol [4]

In general, a high-fiber diet is suggested if the cholesterol level is too high. Cholesterol can be lowered by taking between 2,000 and 4,000 milligrams of glucomannan every day. It is best to take glucomannan as a capsule with meals throughout the day, such as 1,000 milligrams in the morning, at noon, and at night. But the best way to take glucomannan is as a powder that you mix into water. Because it blends better with the food in the stomach that way.

It’s important to drink enough so that the glucomannan can expand in the stomach. One or two glasses of water per dose is best. Dietary fibers only help lower cholesterol if you eat them regularly.

Glucomannan: Be careful if you are pregnant or breastfeeding, sick, or taking medicine.

When a woman is pregnant or breastfeeding, she should talk to her doctor about the supplement. Not enough is known about safety yet.

People with a blockage in their intestines shouldn’t take it because it makes the intestines swell up.

When taking glucomannan, people with diabetes who need to take medicine should check their blood sugar levels more often. Glucomannan lowers how much sugar is in the blood. Hypoglycemia could happen. Diabetes drugs include metformin (such as Glucophage®), glitazones (such as Pioglitazone®), and sulfonylureas (such as Maninil®).

Due to the gel that forms in the intestine, glucomannan can make it harder for medicines to be absorbed. Because of this, less of the active ingredient can get into the blood. So, at least two hours should pass between each one.[5]

Oat fiber is a natural way to lower cholesterol.

The way that oat beta-glucan works

A bowl of oatmeal in wood

There is a lot of beta-glucan in oatmeal. This fiber helps to lower cholesterol levels in a natural way. iStock/Getty Images Plus/Vladislav Nosick

Beta-glucans are a type of fiber that comes from the outside of the oat grain. Beta-glucans bind to bile acids in the intestine, making it easier for the body to get rid of them.low vitamin d and high cholesterol found, After that, the body has to make more bile acids. To do this, he eats cholesterol, which causes his cholesterol level to drop on its own.

A review article shows that beta-glucans cause people with slightly high cholesterol levels to have less fat in their bodies. Reviewing the results of many high-quality studies shows that beta-glucans taken as part of a meal can even lower levels that are already significantly high. On average, total cholesterol went down by almost 12 mg/dL, and LDL cholesterol went down by almost 10 mg/dL. This is between 5 and 10 percent of the value at the start.


Beta-glucans aren’t just found in cereals, by the way. It is also in mushrooms. Because of this, it could also… [more info]

How much oat beta-glucan to take and how much is recommended

Fibraform Beta Glucan

At least 3 grams (3 milligrams) of beta-glucans should be eaten every day to lower cholesterol levels in a healthy way. It’s important to eat regularly. About 80 grams of oatmeal is about the right amount. This amount is also found in 40 grams of oat bran.


If you don’t want to eat 80 grams of oatmeal every day, there are other ways to eat it. [more info][7]

Oat beta-glucan: Keep an eye on it during pregnancy and breastfeeding, and if you get sick or take medicine.

Also, oats are safe to eat while pregnant. But there are no data on how to separate beta-glucans from preparations. Talk to a doctor about the intake.

Oat beta-glucans shouldn’t be taken by people who have a sudden blockage in their gut.

Oats contain a small amount of gluten, so people with celiac disease should be careful when eating them. Some people with this condition can eat oats without any problems, while others can’t. So, you can try oat beta-glucans to see if they work well together.

Because they form a gel in the gut, soluble fibers like oat beta-glucans can slow down how well medicines work. Because of this, less of the active ingredient can get into the blood. So, at least two hours should pass between each one.

Blood sugar can be lowered by beta glucans. Hypoglycemia can happen to people with diabetes who take metformin (such as Biocos® or Diabesin®) or insulin (such as Humalog® or NovoRapid®). So, you should keep a close eye on your blood sugar.

Extract of artichoke: make less cholesterol, get rid of more

The way that artichoke extract works

There are artichokes on the table.

An artichoke extract does two good things at once. The bad LDL cholesterol goes down, and the good HDL cholesterol goes up.

Scientists think that the ingredients in the artichoke leaves stop the liver from making new cholesterol. Artichoke leaves also help the body get rid of cholesterol by increasing the production of bile acids and the flow of bile into the intestine. The bile acids are held together by an artichoke ingredient called inulin. Because of this, the body can no longer take in bile acids. low vitamin d and high cholesterol levels, He has to use cholesterol to make new bile acids, so his cholesterol level goes down.

Several studies show that artichoke extract can reduce the amount of fat in the blood. Most importantly, compared to placebo drugs, there was a drop in the amount of LDL cholesterol that was too high.


There is evidence that other plants, such as the, can also help lower cholesterol levels. [more info][8]

How much artichoke extract to take and how often

400 to 600 milligrams of artichoke extract per day are needed to lower cholesterol levels in a healthy way. The best time to take artichoke extract is before a meal. This also helps with digestion.

Experts on micronutrients usually suggest a high-quality extract instead of powdered artichoke leaves because extracts have more of the active ingredients.

Artichoke extract should be used with caution during pregnancy and breastfeeding, if you have gallstones, or if you are taking medicine.

As a safety measure, women who are pregnant or breastfeeding shouldn’t take artichoke extract or talk to their doctor about it. There are still not enough safety studies.

People who have been told they have gallstones should also avoid artichoke extract. The active ingredients in artichoke extract make the body make more bile, which can block the bile ducts and cause gallbladder colic.

The extract of artichoke may help lower blood sugar. If a person with diabetes is taking medicine, they should check their blood sugar often to avoid hypoglycemia. This is true for diabetes medicines like metformin (Diabesin®) and glibenclamide (Euglucon®) as well as insulin like Huminsulin®, Insuman® Rapid, and Actrapid®.

Artichoke extract can also cut down on anticoagulants like coumarin. If you take these blood thinners, you should talk to your doctor. Your doctor can check your “Quick value” (also called “prothrombin time”) regularly and change the dose if needed. These include the active ingredients phenprocoumon (found in Marcumar®, Falithrom®, and Marcuphen®) and warfarin (Coumadin®).

Botanicals from red grapes lower LDL cholesterol, which damages blood vessels.

The way that OPC and Resveratrol work

Oligomeric proanthocyanidins (OPC) and resveratrol are two important plant compounds that are found in red grapes. Both substances are antioxidants, which means they are good for the blood vessels. This keeps cholesterol from changing (oxidizing) in the walls of the blood vessels. Heart diseases are sometimes caused by oxidized LDL cholesterol. It makes the blood vessels swell up.

Also, the plant substances could lower cholesterol. Two studies showed that high doses of resveratrol lowered total cholesterol and, in some cases, LDL cholesterol in people with diabetes or metabolic syndrome. But two other reviews don’t back up this claim. Even though it’s not clear if OPC and resveratrol lower cholesterol, they may still protect: in a preliminary study, people who took resveratrol had 20% less oxidized cholesterol. The same thing happens with OPC. So, it’s likely that OPC and resveratrol will protect the blood vessels and lower the risk of hardening of the arteries or a heart attack.

How much OPC and resveratrol you should take and how often

Experts on micronutrients say to take 100 to 200 milligrams of OPC and 10 to 20 milligrams of resveratrol to stop changes in LDL cholesterol and protect the blood vessels. For example, you can buy OPC and resveratrol in the form of grape seed extract. Experts recommend a product that says what kinds of plant substances are in it.

It is best to take OPC and resveratrol with food so that your body can handle them better. But at that point, the meal should have as little protein as possible. Proteins make it harder for the intestine to take in OPC.

Be careful with OPC and resveratrol if you are pregnant, breastfeeding, or taking medicine.

There haven’t been enough studies done on pregnancy and breastfeeding. So, you should only take OPC and resveratrol pills after talking to a doctor.

Both OPC and resveratrol change how blood clots. So, it’s possible that the two plant substances make blood-thinning medicines work better. So, talk to the doctor about the intake during the consultation. For example, the doctor can check how well the blood is clotting. Some of these drugs are acetylsalicylic acid (Aspirin®), clopidogrel (Plavix®, Iscover®), diclofenac (Voltaren®), ibuprofen (Neuralgin®), naproxen (Dolormin®), [10]dalteparin (Fragmin®), heparin (Thrombophob®, Vetren®), and warfarin (Coumadin®).

Does not getting enough vitamin D cause high cholesterol?

The way vitamin D works

Even though it’s not clear how vitamin D lowers high cholesterol levels, several observational studies have already shown a link between a good supply of vitamin D and low cholesterol levels. If the study participants had more vitamin D (over 30 nanograms per milliliter), their cholesterol levels were also lower. People with a deficiency, on the other hand, had higher fat levels.

If someone didn’t get enough vitamin D, the amount they were supposed to get lowered their total cholesterol. Several studies, such as those on people with polycystic ovary syndrome (PCOS) or liver and kidney diseases, show this to be true. diet for low vitamin d and high cholesterol,But there are also other works that don’t show a cause.

Vitamin D is also important for the heart muscle and helps keep blood pressure in check. In this way, having enough vitamin D could lessen the effects of having too much cholesterol. So, a lack of something should be avoided.

In the best case, the dose of vitamin D is based on the amount of vitamin D in the blood. This is the only way to make up for a deficiency effectively. In the article about vitamin D, you can find out everything you need to know about the right dose to take if you don’t have enough.

If you don’t know how much vitamin D you have, you can take between 1,000 and 2,000 international units per day to help your body process cholesterol.

Vitamin D is best taken with food because it dissolves in fat and can only be absorbed in the intestines when fat is present. You don’t need much fat from food.

Have a lab check your vitamin D level.

In cases of high cholesterol and heart disease, it makes sense to measure the amount of vitamin D in the blood. This is the only way to effectively make up for a possible lack of vitamin D.

In the lab, 25-(OH)-vitamin D is measured. This is a type of vitamin D that is found in the blood. Blood serum, which is blood fluid without the blood cells, is used for this.

The best amount of vitamin D in the blood serum is between 40 and 60 nanograms per milliliter, or between 100 and 150 nanomoles per liter.

Vitamin D: Something to think about when it comes to diseases and medicines

People with kidney disease shouldn’t take vitamin D without first talking to their doctor. Their mineral balance is off, and they may have too much calcium in their bodies. Since vitamin D helps the intestine absorb calcium, calcium levels in the blood can get too high. People who have kidney stones, which are calcium-based stones, also need to be careful.

Vitamin D shouldn’t be taken by people with sarcoidosis (Boeck’s disease), an inflammatory disease of the connective tissues. People with sarcoidosis also often have high blood calcium levels, which could get even higher if they took vitamin D. The same is true for people who have pancreatitis.

Drainage drugs (diuretics) from the thiazide group with the active ingredients hydrochlorothiazide (like Esidrix®), xipamide (like Aquaphor®), and indapamide (like Natrilix®) stop the kidneys from getting rid of calcium. This means that the blood calcium level goes up. Since vitamin D also raises the amount of calcium in the body, it can’t be taken with thiazides unless the calcium level is checked often.

Most likely, phospholipids stop the body from absorbing cholesterol in the gut.

Phospholipids and how they work

On a table is a glass carafe of sunflower oil, a sunflower, and sunflower seeds.

Sunflower oil has many different kinds of phospholipids. These should be able to stop the intestine from taking in cholesterol from food. Photo by tashka2000/iStock/Getty Images Plus

Choline can be found in soy and eggs as phosphatidylcholine (lecithin). Researchers think that it might stop the body from taking in cholesterol. But phosphatidylcholine has other effects as well. It probably helps cholesterol get to the liver and then out of the body through the intestines via the bile.

professional know-how

In the intestine, the pieces of fat that have been broken up form micelles with cholesterol and bile acids. These micelles then stick to the… [more info]

Some early studies show that taking a lot of phosphatidylcholine could improve cholesterol levels. Specifically, the bad LDL cholesterol went down and the good HDL cholesterol went up. Phosphatidylcholine may also be good for reducing inflammation. Overall, this means that it could help lower cholesterol in a natural way.

learn more about  The Oxidized Cholesterol Strategy

To lower cholesterol, you can try taking between 1,000 and 2,000 milligrams of phosphatidylcholine per day. Phosphatidylcholine should be taken with food so it can directly stop the body from taking in cholesterol.

In general, it makes sense to talk to a doctor or micronutrient expert about taking phosphatidylcholine for a long time if you have heart disease. Some people have problems with their gut bacteria. From phosphatidylcholine, bacteria in the gut could then make the chemical TMAO (trimethylamine-N-oxide). If there is a lot of TMAO in the blood for a long time, the risk of heart disease, heart attack, or diabetes could go up even more. A review article, however, does not yet show a direct link between phosphatidylcholine and heart diseases. The doctor can watch how the disease progresses and make sure it isn’t getting worse.


Soy is often used to get phosphatidylcholine. If you are allergic to soy, you can’t eat this. … [more info]

Phosphatidylcholine: Care should be taken during pregnancy, breastfeeding, when taking medicine, and when sick.

Since there aren’t enough studies on the use of phosphatidylcholine (lecithin) during pregnancy and breastfeeding, it shouldn’t be taken as a precaution or only after talking to a doctor.

Anticoagulants of the coumarin type and phosphatidylcholine may interact with each other. These include things like the active ingredients in Falithrom®, Marcumar®, and warfarin (which is in Coumadin®), among others. Talk to the doctor about how much to take. This can help keep the blood from clotting.

Phosphatidylcholine shouldn’t be taken by people who have kidney disease. When choline is broken down, things are made that are bad for you if you don’t get rid of them.

If you take choline regularly and have heart disease, weak kidneys or liver, gallstones, or diabetes, you should work with a doctor. Trimethylamine-N-oxide can be made from choline when the intestinal flora is out of balance. This makes the risk of these diseases even higher.

To be safe, people with cancer shouldn’t take a lot of phosphatidylcholine either. Cancer cells can change how phosphatidylcholine is broken down. No one has looked into what happens when you eat more phosphatidylcholine than you normally would.

Antioxidants keep blood vessels from being damaged by high levels of cholesterol.

way that antioxidants work

When the level of cholesterol in the blood is high, antioxidants protect the blood vessels because LDL cholesterol can oxidize in the blood. This means that free radicals damage it and cause it to build up over time in the walls of the blood vessels. This is the main thing that leads to atherosclerosis (hardening of the arteries). Because of this, for example, the chance of having a heart attack goes up.

Some antioxidants that protect blood vessels are vitamins C and E, the minerals zinc and selenium, and coenzyme Q10. Still to be found out is whether or not these nutrients can also lower high cholesterol. But the data is good news for some:

Coenzyme Q10: Even though coenzyme Q10 didn’t always have an effect on cholesterol, it usually did have an effect on other things, like oxidative stress and the metabolism as a whole.

Vitamin C: One study found that 500 milligrams of vitamin C could mostly lower the LDL value. But there aren’t any set dates yet. Researchers think that for vitamin C to work better, it would have to be taken for longer than twelve weeks and in small amounts (less than 1,000 milligrams).

Vitamin E: There is evidence that a subgroup of vitamin E called tocotrienols helps lower high cholesterol levels. With 50 to 200 milligrams of tocotrienols per day, this has been seen. But not every study review showed that this was true.

Even though the data are still contradictory as a whole, a diet high in antioxidants is usually recommended for people with high cholesterol. This would protect the blood vessels from the effects of having too much cholesterol.

How much antioxidants to take and how often

The best way to protect the blood vessels is to take antioxidants in small amounts and in combination with other antioxidants. Antioxidants work better when they work together. For example, vitamin E needs vitamin C to recover after it has neutralized a free radical.

It makes sense to take 80 to 200 milligrams of vitamin C, 20 to 40 milligrams of vitamin E, 5 to 10 milligrams of zinc, 50 to 70 micrograms of selenium, and 50 to 100 milligrams of coenzyme Q10 every day.

In particular, antioxidants that dissolve in fat, like vitamin E, must be taken with food because they can only get into the blood when fat is present.

Blood in a test tube in a hand

A blood test in the lab can tell what the antioxidant status is. Photo by utah778/iStock/Getty Images Plus

Find out the status of oxidized LDLs and antioxidants

Researchers think that the most important sign of cardiovascular disease is not the amount of cholesterol but how it is oxidized. So, it makes sense to check the blood for the harmful oxidized LDL cholesterol. Micronutrient experts recommend this blood test because it can tell if deposits have already caused damage to the blood vessels (hardening of the arteries). It can also mean that you don’t get enough antioxidants.


Depending on the lab and the way the test is done, the normal values for antioxidant… [more info]

Antioxidants should be thought about during pregnancy and breastfeeding, as well as when sick or taking medicine.

During pregnancy, it is best to take 110 milligrams of vitamin C. The doctor should be talked to about values.

Since vitamin C makes it easier for the body to absorb iron, it can only be taken under the supervision of a doctor when there is too much iron in the body (hemochromatosis).

If you have chronic kidney disease or other kidney problems, you shouldn’t take zinc or selenium. Zinc and selenium build up in the body when the kidneys aren’t working well.

Selenium might change the chance of getting diabetes. Selenium shouldn’t be taken by people at high risk of diabetes unless their blood is being checked. If you already have diabetes, you should talk to a doctor or an expert on micronutrients. The same is true for cancer and treatments for it.

Coenzyme Q10 can lower the amount of sugar in the blood. This is why diabetics need to check their blood sugar often to avoid hypoglycemia.

In tests on animals, vitamin C made the blood cancer drug bortezomib work less well. So, it should only be taken during this kind of therapy after talking to the doctor.

Zinc can bind to some drugs, making them less effective. This happens with antibiotics (like gyrase inhibitors and tetracyclines like Ciloxan®, Norfluxx®, or Supracyclin®) and drugs for osteoporosis (like bisphosphonates like Fosamax®, Bonefos®, and Didronel®). At least two hours should pass between each dose.

Coenzyme Q10 and anticoagulants are something you should talk to a doctor about. Coenzyme Q10 can make the medicine not work as well. These include so-called coumarins with the active ingredient phenprocoumon (Marcumar®, Falithrom®, Phenpro®) and warfarin (Coumadin®).

B vitamins help keep blood vessels healthy and lower cholesterol.

B vitamins and how they work

Homocysteine needs B vitamins to be broken down. If you don’t get enough vitamins, homocysteine builds up in your blood. It is thought to be a cell toxin that is linked to many diseases, such as heart diseases. When there is a lot of homocysteine in the blood, there is often a lot of fat in the blood as well. Most likely, B vitamins also have a direct effect on how cholesterol is made and used. Also, vitamin B2 has an antioxidant effect that could help lessen the damage that oxidized cholesterol does.

Researchers have seen that high LDL cholesterol is less harmful when folic acid levels are high. So, it could protect against damage to the blood vessels. In a large study, people who took folic acid had lower levels of total cholesterol and other fats (triglycerides). Folic acid also decreased some measures of inflammation and should have a positive effect on vascular health as a whole.

Overall, there is still a lot to learn about B vitamins and cholesterol. But B vitamins that lower homocysteine should be paid attention to so that the blood vessels don’t have to work harder. B vitamins could help reduce the risk factors for heart disease, especially in people who aren’t getting enough of them.


High-dose therapy with nicotinic acid, which is a form of niacin, has been used for a long time in high… [more info]

B vitamins: how much to take and how often

Micronutrient experts say that 2 to 5 milligrams of vitamin B6, 25 to 50 micrograms of vitamin B12 (as methylcobalamin), and 200 to 500 micrograms of folic acid are a good way to get enough B vitamins. If the homocysteine levels are already high, the dose can be increased with the help of a doctor or an expert on micronutrients. To make sure your body can handle them, it’s best to take B vitamins with food.

Folic acid should be taken in the form that works best. Because of a genetic change, about half of all people are less able or even unable to change folic acid into the active form that the body needs. You can avoid this genetic flaw by taking 5-methyltetrahydrofolate, which is the active form of folic acid (5-MTHF).

Check your homocysteine level

Having your homocysteine levels checked is a good idea, especially if your cholesterol levels are high, so that the homocysteine doesn’t do more damage to your blood vessels.

Most of the time, homocysteine is measured in the blood plasma, which is the liquid part of the blood that doesn’t have blood cells. Blood plasma should have less than 10 micromoles per liter.

B vitamins are important to pay attention to when pregnant, breastfeeding, sick, or taking medicine.

When you are pregnant or breastfeeding, you should only take a lot of B vitamins if you know you need them. Talk to your doctor about the problem.

In kidney disease, vitamin B12 shouldn’t be used as cyanocobalamin. Cyanocobalamin is probably bad for people in large amounts. Also, people whose kidneys and livers don’t work as well could have more vitamin B12 in their blood. Then you shouldn’t take folic acid in high doses.

Folic acid can protect against cancer if you get enough of it. Under certain circumstances, however, taking high doses of folic acid over a long period of time can also help a disease get worse or, if it is in its early stages, help it grow. So, if you have cancer, you should talk to your doctor before taking more than 200 micrograms of folic acid every day. A consultation also applies to vitamin B12.

Infectious diseases are treated with drugs that have the active ingredients trimethoprim (like Infectotrimet®), proguanil (like Paludrine®), and pyrimethamine (like Daraprim®). Folic acid makes these medicines less useful.

Omega-3 fatty acids lower the chance that high cholesterol will cause problems.

Omega-3 fatty acids and how they work

Bottle and capsules in hands

Omega fatty acids from fish or linseed oil keep blood vessels from getting clogged up with fat. These are in the form of capsules. Photo by FotoDuets, iStock, or Getty Images Plus

Omega-3 fatty acids from fish or linseed oil help keep the blood vessels flexible. They slow down the buildup of fat in the blood vessels and make the blood flow more easily. Also, they lower the amount of inflammation in the blood, which can cause the blood vessels to stiffen. This lowers the chance of getting other diseases.

Several reviews say that omega-3 fatty acids probably also help the lipids in the blood. Depending on what illness the person had before, the triglycerides, total cholesterol, and LDL cholesterol all went down. At the same time, some studies found that the good HDL cholesterol level went up.

Omega-3 fatty acids can come from many different places. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in fish and algae. Alpha-linolenic acid (ALA), on the other hand, is found in nuts and seeds. The different fatty acids may have different effects. For example, EPA lowers total cholesterol by a little bit, while DHA temporarily raises LDL cholesterol. It brings down triglycerides by a lot. Overall, both are good for the health of the heart and blood vessels. Another review shows that ALA that comes from plants also lowers cholesterol levels.

In the end, though, it seems that EPA and DHA together are the best way to lower the risk of heart disease. Experts on micronutrients recommend preparations with fish and algae oil, especially when high cholesterol and triglyceride levels go together.

Omega-3 fatty acids: how much and how often

Omega-3 fatty acids should be taken every day between 1,500 and 2,000 milligrams if the cholesterol level is too high. It’s best to have a lot of the omega-3 fatty acid EPA, like at least 800 milligrams. EPA is very good at reducing inflammation. Omega-3 fatty acids, even when taken in higher doses, are thought to be safe and well tolerated.

Omega-3 fatty acids should be taken with food because this is the best way for them to get from the intestines to the blood.


Attention: When fish oil is made, omega-3 fatty acids often lose some of their power. … [more info]

The omega-3 index measures how good the supply of omega-3s is.

The omega-3 index shows how many omega-3 fatty acids there are and how good they are. The blood test is especially helpful if there are other risk factors, like obesity, high blood pressure, or heart problems, along with high cholesterol levels.

The blood is used to check the omega-3 index. A percentage is used to figure out how much omega-3 fatty acids are in the red blood cells. If the omega-3 index is over 8 percent, the supply is very good. If your index is less than 4%, on the other hand, you aren’t getting enough care and are more likely to get heart disease.

professional know-how

Lp-PLA2, which stands for lipoprotein-associated phospholipase A2, is a sign of heart disease. … [more info]

Omega-3 fatty acids should be thought about when taking blood thinners, getting sick, or having surgery.

Because omega-3 fatty acids in doses of 1,000 milligrams per day make the blood flow better and thin the blood, a doctor should be consulted before taking blood-thinning drugs. To avoid unwanted interactions, the dose of the medicine may need to be changed.

Coumarin derivatives and warfarin are two types of blood thinners. Acetylsalicylic acid (ASA), heparin, and the so-called “new oral anticoagulants” (apixaban, dabigatran, edoxaban, and rivaroxaban) are also blood thinners.

Omega-3 fatty acids may affect how much sugar is in the blood. To avoid hypoglycemia, diabetics who take medicine should check their blood sugar levels more often when they first start taking them. Changes may need to be made to the medicine.

Omega-3 fatty acids should not be taken in the event of sudden liver disease, acute pancreatitis or gallbladder inflammation. People with a blood clotting disorder should also avoid taking omega-3 fatty acids.

If a surgery is coming up, doctors tell their patients to stop taking omega-3 fatty acids one to two weeks before the surgery so there isn’t a lot of bleeding. After that, there’s no reason not to take them again.

Dosages at a glance

Recommendations per day for people with high cholesterol


Vitamin D

If applicable, 1,000 to 2,000 International Units (IU)

depending on the mirror as well

vitamin E

20 to 40 mg (mg)

vitamin C

between 80 and 200 mg

Vitamin B6

2 to 5 mg

Vitamin B12 (as methylcobalamin)

between 25 and 50 micrograms (g)

Folic acid (as directly usable 5-MTHF)

between 200 and 500 micrograms



5 to 10 milligrams


50–70 micrograms

plant matter and dietary fiber


between 2,000 and 4,000 mg

Oat Beta Glucan

at least 3,000 milligrams

Extract of Artichoke

400 to 600 milligrams

Grape seed OPC

100 to 200 milligrams


10–20 milligrams



1,000 to 2,000 mg

Coenzyme Q10

50 to 100 mg

Fatty acids with omega-3

1,500 milligrams to 2,000 milligrams, with a very high

EPA percentage (at least 800 milligrams)

A quick look at useful lab tests

Useful blood tests for elevated cholesterol levels

normal values

Vitamin D

40 to 60 nanograms per milliliter, or 100 to

150 nanomoles per liter (nmol/L)

Total Antioxidant Status (Serum)

1.13 to 1.57 millimoles per liter (mmol/L)

homocysteine ​​ (plasma)

less than 10 mol/l (micromoles per liter).

Omega 3 index

5 to 8 percent (better over 8 percent)

Start over

Vote in favor of medicines with micronutrients

Coenzyme Q10 and vitamin D help ease muscle pain caused by statins.

Most people who take statins feel pain in their muscles. They are also the main reason why many people stop taking statins. But coenzyme Q10 and vitamin D can help to lessen these side effects.

It is especially important to make up for a lack of vitamin D if you want to make statins easier to take. Statins also stop the body from making coenzyme Q10. This could also be why the muscles have nerve problems. So, the combined intake makes sense to keep from getting too little. Vitamin D should be taken in doses of 1,000 to 2,000 international units per day. Coenzyme Q10 should be taken in doses of 100 to 300 milligrams per day. Here, you can learn everything about coenzyme Q10, vitamin D, and statins.


Statins only work if vitamin D stores are full enough. [more info]

Fibrate levels go up when homocysteine levels go up.

Fibrates that lower cholesterol, like bezafibrate and fenofibrate, raise the amount of homocysteine in the blood. But homocysteine hurts cells and should be kept at a low level because of this. For homocysteine to be broken down, you need B vitamins: 5 to 15 milligrams of vitamin B6, 200 to 500 micrograms of folic acid (5-MTHF), and 250 to 500 micrograms of vitamin B12.

Studies have also found that fibrates lower the amount of vitamin E and coenzyme Q10 in the blood. To make up for it, you should take between 100 and 200 milligrams of coenzyme Q10 and up to 150 milligrams of vitamin E.

Anion exchange resins cause deficiencies in fat-soluble nutrients

Cholestyramine and other anion exchange resins lower cholesterol levels by making it harder for the body to digest fat. Long-term use of these cholesterol-lowering drugs can make you lack vitamins that dissolve in fat and other important nutrients. Carotenoids and vitamins A, D, E, and K are some of these. In addition, the intake of folic acid, vitamin B12, vitamin C, magnesium and zinc is reduced.

In order to avoid a deficiency, it makes sense to eat foods that are particularly rich in vitamins – good food sources can be found in articles on the individual vitamins – or fat-soluble vitamins in the form of a combination preparation. Make sure the preparation has at least the recommended amount of 400 micrograms of vitamin A, 1,000 international units of vitamin D, 13 milligrams of vitamin E, and 75 micrograms of vitamin K, preferably from K1 and K2.


The combination drug should be taken either an hour before or four hours after the other drugs. [more info]

Dosages at a glance

Recommendation per day for medicines that lower cholesterol


Coenzyme Q10

between 100 and 300 mg (mg)

Vitamin D

1,000 to 2,000 International Units (IU) each

based on levels of vitamin D


Vitamin B6

5 to 15 mg

Vitamin B12 (ideally as active methylcobalamin)

250 micrograms (g) to 500 g

Folic acid (as a directly usable form)

between 200 and 500 micrograms

Coenzyme Q10

100 to 200 milligrams

vitamin E

as much as 150 mg

resins that swap ions

Vitamin A

400 milligrams

Vitamin D

1,000 international units

vitamin E

13 milligrams

vitamin k

75 g (ideally from K1 and K2)

Start over


High cholesterol can be caused by eating a lot of sugar and fat and not moving around enough. At first, no one says anything bad. But if the cholesterol level is too high all the time, the risk of heart disease goes up. Getting rid of the LDL value and oxidative stress is especially important.

Within the framework of micronutrient medicine, high cholesterol levels can be treated naturally. low vitamin d and high cholesterol,Dietary fibers like glucomannan from konjac roots and beta-glucans from oats, as well as plant substances from artichoke leaves, help lower cholesterol levels by preventing absorption in the intestine or encouraging the body to get rid of cholesterol. Phospholipids, which are fat-like substances, also help this process.

Antioxidants, B vitamins, and omega-3 fatty acids protect blood vessels from damage caused by oxidized cholesterol, so they should also be part of micronutrient therapy. LDL cholesterol doesn’t get oxidized when OPC and resveratrol from red grapes are in the body. The hardening of the arteries is caused by this cholesterol. More research needs to be done to find out if OPC and resveratrol can also bring down high cholesterol levels. Since people with high cholesterol levels often don’t get enough vitamin D, the levels should be watched. But it’s still not clear if vitamin D lowers cholesterol or not.

Without statins, it’s not always possible to lower high cholesterol. Statins do have side effects, though. One of the most common is muscle pain. So, you should take coenzyme Q10 and vitamin D supplements here. Most of the time, the pain can be lessened or stopped. Fibrates, on the other hand, raise the level of homocysteine, which is why it’s important to get enough B vitamins. Anion exchange resins, like cholestyramine, can make it hard to get enough fat-soluble vitamins.

learn more about  The Oxidized Cholesterol Strategy

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